help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SUTO, A.
Right arrow Articles by IWAMOTO, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SUTO, A.
Right arrow Articles by IWAMOTO, I.

Am. J. Respir. Crit. Care Med., Volume 164, Number 4, August 2001, 680-687

Role of CD4+ CD25+ Regulatory T Cells in T Helper 2 Cell-mediated Allergic Inflammation in the Airways

AKIRA SUTO, HIROSHI NAKAJIMA, SHIN-ICHIRO KAGAMI, KOTARO SUZUKI, YASUSHI SAITO, and ITSUO IWAMOTO

Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan

It has recently been shown that CD4+ CD25+ T cells are immunoregulatory T cells that prevent CD4+ T cell-mediated organ-specific autoimmune diseases. To determine whether CD4+ CD25+ T cells downregulate Th2 cell-mediated allergic inflammation in the airways, we studied antigen-induced eosinophil recruitment in the airways in BALB/c Rag-2-/- mice transferred with CD4+ CD25+ T cell-depleted or unfractionated T cells from ovalbumin-specific TCR transgenic mice. Antigen-induced eosinophil recruitment into the airways was significantly decreased in the mice transferred with CD4+ CD25+ T cell-depleted splenocytes as compared with those transferred with unfractionated splenocytes. On the other hand, the depletion of CD4+ CD25+ T cells increased antigen-induced neutrophil and T cell recruitment in the airways of the mice. The depletion of CD4+ CD25+ T cells also decreased antigen-induced IL-4 and IL-5 production in the airways of the mice. Finally, the depletion of CD4+ CD25+ T cells prevented antigen-induced Th2 cell differentiation in vitro but increased the differentiation of Th1 cells. These results indicate that CD4+ CD25+ T cells modulate the Th1 and Th2 cell balance toward Th2 cells and thus upregulate Th2 cell-mediated allergic inflammation in the airways.

Keywords: allergic inflammation; eosinophils; CD4+ CD25+ T cells; Th1/Th2 cells




This article has been cited by other articles:


Home page
 J. Immunol.Home page
K. Saito, M. Torii, N. Ma, T. Tsuchiya, L. Wang, T. Hori, D. Nagakubo, N. Nitta, S. Kanegasaki, K. Hieshima, et al.
Differential Regulatory Function of Resting and Preactivated Allergen-Specific CD4+CD25+ Regulatory T Cells in Th2-Type Airway Inflammation
J. Immunol., November 15, 2008; 181(10): 6889 - 6897.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Joetham, K. Takeda, N. Miyahara, S. Matsubara, H. Ohnishi, T. Koya, A. Dakhama, and E. W. Gelfand
Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction
PNAS, September 18, 2007; 104(38): 15057 - 15062.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Abdala-Valencia, J. Earwood, S. Bansal, M. Jansen, G. Babcock, B. Garvy, M. Wills-Karp, and J. M. Cook-Mills
Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1111 - L1125.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Joetham, K. Takada, C. Taube, N. Miyahara, S. Matsubara, T. Koya, Y.-H. Rha, A. Dakhama, and E. W. Gelfand
Naturally Occurring Lung CD4+CD25+ T Cell Regulation of Airway Allergic Responses Depends on IL-10 Induction of TGF-beta
J. Immunol., February 1, 2007; 178(3): 1433 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Hubeau, I. Apostolou, and L. Kobzik
Targeting of CD25 and Glucocorticoid-Induced TNF Receptor Family-Related Gene-Expressing T Cells Differentially Modulates Asthma Risk in Offspring of Asthmatic and Normal Mother Mice
J. Immunol., February 1, 2007; 178(3): 1477 - 1487.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Baumgart, F. Tompkins, J. Leng, and M. Hesse
Naturally Occurring CD4+Foxp3+ Regulatory T Cells Are an Essential, IL-10-Independent Part of the Immunoregulatory Network in Schistosoma mansoni Egg-Induced Inflammation
J. Immunol., May 1, 2006; 176(9): 5374 - 5387.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Longhi, M. J. Hussain, R. R. Mitry, S. K. Arora, G. Mieli-Vergani, D. Vergani, and Y. Ma
Functional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis
J. Immunol., April 1, 2006; 176(7): 4484 - 4491.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Sawicka, G. Dubois, G. Jarai, M. Edwards, M. Thomas, A. Nicholls, R. Albert, C. Newson, V. Brinkmann, and C. Walker
The Sphingosine 1-Phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-Regulatory Cells and Enhances Their Functional Activity
J. Immunol., December 15, 2005; 175(12): 7973 - 7980.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
I. P. Lewkowich, N. S. Herman, K. W. Schleifer, M. P. Dance, B. L. Chen, K. M. Dienger, A. A. Sproles, J. S. Shah, J. Kohl, Y. Belkaid, et al.
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
J. Exp. Med., December 5, 2005; 202(11): 1549 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. M. Hawrylowicz
Regulatory T cells and IL-10 in allergic inflammation
J. Exp. Med., December 5, 2005; 202(11): 1459 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. J. M. van Oosterhout and N. Bloksma
Regulatory T-lymphocytes in asthma
Eur. Respir. J., November 1, 2005; 26(5): 918 - 932.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D S Robinson
Regulation: the art of control? Regulatory T cells and asthma and allergy
Thorax, August 1, 2004; 59(8): 640 - 643.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Stassen, H. Jonuleit, C. Muller, M. Klein, C. Richter, T. Bopp, S. Schmitt, and E. Schmitt
Differential Regulatory Capacity of CD25+ T Regulatory Cells and Preactivated CD25+ T Regulatory Cells on Development, Functional Activation, and Proliferation of Th2 Cells
J. Immunol., July 1, 2004; 173(1): 267 - 274.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Cosmi, F. Liotta, R. Angeli, B. Mazzinghi, V. Santarlasci, R. Manetti, L. Lasagni, V. Vanini, P. Romagnani, E. Maggi, et al.
Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines
Blood, April 15, 2004; 103(8): 3117 - 3121.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Jaffar, T. Sivakuru, and K. Roberts
CD4+CD25+ T Cells Regulate Airway Eosinophilic Inflammation by Modulating the Th2 Cell Phenotype
J. Immunol., March 15, 2004; 172(6): 3842 - 3849.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y.-S. Hahn, C. Taube, N. Jin, L. Sharp, J. M. Wands, M. K. Aydintug, M. Lahn, S. A. Huber, R. L. O'Brien, E. W. Gelfand, et al.
Different Potentials of {gamma}{delta} T Cell Subsets in Regulating Airway Responsiveness: V{gamma}1+ Cells, but Not V{gamma}4+ Cells, Promote Airway Hyperreactivity, Th2 Cytokines, and Airway Inflammation
J. Immunol., March 1, 2004; 172(5): 2894 - 2902.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Aronica, S. McCarthy, S. Swaidani, D. Mitchell, M. Goral, J. R. Sheller, and M. Boothby
Recall Helper T Cell Response: T Helper 1 Cell-resistant Allergic Susceptibility without Biasing Uncommitted CD4 T Cells
Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 587 - 595.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y.-S. Hahn, C. Taube, N. Jin, K. Takeda, J.-W. Park, J. M. Wands, M. K. Aydintug, C. L. Roark, M. Lahn, R. L. O'Brien, et al.
V{gamma}4+ {gamma}{delta} T Cells Regulate Airway Hyperreactivity to Methacholine in Ovalbumin-Sensitized and Challenged Mice
J. Immunol., September 15, 2003; 171(6): 3170 - 3178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. L. Hardy, L. Kenins, A. C. Drew, J. M. Rolland, and R. E. O'Hehir
Characterization of a Mouse Model of Allergy to a Major Occupational Latex Glove Allergen Hev b 5
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1393 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A.-C. Field, L. Caccavelli, M.-F. Bloch, and B. Bellon
Regulatory CD8+ T Cells Control Neonatal Tolerance to a Th2-Mediated Autoimmunity
J. Immunol., March 1, 2003; 170(5): 2508 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Xu, H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, J. Alexander, and F. Y. Liew
CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice
J. Immunol., January 1, 2003; 170(1): 394 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
A M A. El-Asrar, S Struyf, S A Al-Kharashi, L Missotten, J Van Damme, and K Geboes
Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis
Br. J. Ophthalmol., October 1, 2002; 86(10): 1175 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 598 - 618.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  ATS State of the Art Course 2008