help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Data Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by JONES, S. L.
Right arrow Articles by TAYLOR, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by JONES, S. L.
Right arrow Articles by TAYLOR, D. R.

Am. J. Respir. Crit. Care Med., Volume 164, Number 5, September 2001, 738-743

The Predictive Value of Exhaled Nitric Oxide Measurements in Assessing Changes in Asthma Control

STUART L. JONES, JOHN KITTELSON, JAN O. COWAN, ERIN M. FLANNERY, ROBERT J. HANCOX, CHRISTENE R. MCLACHLAN, and D. ROBIN TAYLOR

Department of Medical and Surgical Sciences and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

Exhaled nitric oxide (eNO) levels are increased in untreated or unstable asthma and measurements can be made easily. Our aim was to assess the usefulness of eNO for diagnosing and predicting loss of control (LOC) in asthma following steroid withdrawal. Comparisons were made against sputum eosinophils and airway hyperresponsiveness (AHR) to hypertonic saline (4.5%). Seventy-eight patients with mild/moderate asthma had their inhaled steroid therapy withdrawn until LOC occurred or for a maximum of 6 wk. Sixty (77.9%) developed LOC. There were highly significant correlations between the changes in eNO and symptoms (p < 0.0001), FEV1 (p < 0.002), sputum eosinophils (p < 0.0002), and saline PD15 (p < 0.0002), and there were significant differences between LOC and no LOC groups. Both single measurements and changes of eNO (10 ppb, 15 ppb, or an increase of > 60% over baseline) had positive predictive values that ranged from 80 to 90% for predicting and diagnosing LOC. These values were similar to those obtained using sputum eosinophils and saline PD15 measurements. We conclude that eNO measurements are as useful as induced sputum analysis and AHR in assessing airway inflammation, with the advantage that they are easy to perform.




This article has been cited by other articles:


Home page
 ChestHome page
M. Malerba, B. Ragnoli, A. Radaeli, and C. Tantucci
Usefulness of Exhaled Nitric Oxide and Sputum Eosinophils in the Long-term Control of Eosinophilic Asthma
Chest, October 1, 2008; 134(4): 733 - 739.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A. Sykes, T. Seemungal, and ICEAD contributors
Recent advances in exacerbations of asthma
Thorax, September 1, 2008; 63(9): 758 - 760.
[Full Text] [PDF]

Home page
 ChestHome page
K. G. Lim and C. Mottram
The Use of Fraction of Exhaled Nitric Oxide in Pulmonary Practice
Chest, May 1, 2008; 133(5): 1232 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Michils, S. Baldassarre, and A. Van Muylem
Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients
Eur. Respir. J., March 1, 2008; 31(3): 539 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. E. Shaw, M. A. Berry, M. Thomas, R. H. Green, C. E. Brightling, A. J. Wardlaw, and I. D. Pavord
The Use of Exhaled Nitric Oxide to Guide Asthma Management: A Randomized Controlled Trial
Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 231 - 237.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J. Batra, T. Pratap Singh, U. Mabalirajan, A. Sinha, R. Prasad, and B. Ghosh
Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels
Thorax, January 1, 2007; 62(1): 16 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Latzin, C. E. Kuehni, D. N. Baldwin, H. L. Roiha, C. Casaulta, and U. Frey
Elevated Exhaled Nitric Oxide in Newborns of Atopic Mothers Precedes Respiratory Symptoms
Am. J. Respir. Crit. Care Med., December 15, 2006; 174(12): 1292 - 1298.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. A. Kharitonov and P. J. Barnes
Exhaled biomarkers.
Chest, November 1, 2006; 130(5): 1541 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D R Taylor, M W Pijnenburg, A D Smith, and J C D Jongste
Exhaled nitric oxide measurements: clinical application and interpretation
Thorax, September 1, 2006; 61(9): 817 - 827.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. F. Gelb, C. Flynn Taylor, C. M. Shinar, C. Gutierrez, and N. Zamel
Role of Spirometry and Exhaled Nitric Oxide To Predict Exacerbations in Treated Asthmatics
Chest, June 1, 2006; 129(6): 1492 - 1499.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. A. Trenga, J. H. Sullivan, J. S. Schildcrout, K. P. Shepherd, G. G. Shapiro, L.-J. S. Liu, J. D. Kaufman, and J. Q. Koenig
Effect of Particulate Air Pollution on Lung Function in Adult and Pediatric Subjects in a Seattle Panel Study
Chest, June 1, 2006; 129(6): 1614 - 1622.
[Abstract] [Full Text] [PDF]

Home page
 Biol Res NursHome page
J. Choi, L. A. Hoffman, G. W. Rodway, and J. M. Sethi
Markers of lung disease in exhaled breath: nitric oxide.
Biol Res Nurs, April 1, 2006; 7(4): 241 - 255.
[Abstract] [PDF]

Home page
 Proc Am Thorac SocHome page
ATS Workshop Proceedings: Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate.
Proceedings of the ATS, January 1, 2006; 3(2): 131 - 145.
[Full Text] [PDF]

Home page
 ChestHome page
F. Buchvald, M. N. Hermansen, K. G. Nielsen, and H. Bisgaard
Exhaled Nitric Oxide Predicts Exercise-Induced Bronchoconstriction in Asthmatic School Children
Chest, October 1, 2005; 128(4): 1964 - 1967.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A.-M. Vints, E. Oostveen, G. Eeckhaut, M. Smolders, and W. A. De Backer
Time-Dependent Effect of Nitrate-Rich Meals on Exhaled Nitric Oxide in Healthy Subjects
Chest, October 1, 2005; 128(4): 2465 - 2470.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. R. Taylor, M. J. Epton, M. A. Kennedy, A. D. Smith, S. Iles, A. L. Miller, M. D. Littlejohn, J. O. Cowan, T. Hewitt, M. P. Swanney, et al.
Bronchodilator Response in Relation to {beta}2-Adrenoceptor Haplotype in Patients with Asthma
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 700 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. D. Smith, J. O. Cowan, K. P. Brassett, S. Filsell, C. McLachlan, G. Monti-Sheehan, G. P. Herbison, and D. R. Taylor
Exhaled Nitric Oxide: A Predictor of Steroid Response
Am. J. Respir. Crit. Care Med., August 15, 2005; 172(4): 453 - 459.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A Bush
How has research in the last five years changed my clinical practice?
Arch. Dis. Child., August 1, 2005; 90(8): 832 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
R Ratnawati and P S Thomas
Exhaled nitric oxide in paediatric asthma
Chronic Respiratory Disease, July 1, 2005; 2(3): 163 - 174.
[Abstract] [PDF]

Home page
 Eur Respir JHome page
P. E. Silkoff
Monitoring nitric oxide: here to stay for bench and bedside
Eur. Respir. J., June 1, 2005; 25(6): 949 - 950.
[Full Text] [PDF]

Home page
 NEJMHome page
A. D. Smith, J. O. Cowan, K. P. Brassett, G. P. Herbison, and D. R. Taylor
Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma
N. Engl. J. Med., May 26, 2005; 352(21): 2163 - 2173.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. Deykin
Targeting Biologic Markers in Asthma -- Is Exhaled Nitric Oxide the Bull's-Eye?
N. Engl. J. Med., May 26, 2005; 352(21): 2233 - 2235.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. Gaston
Inhaled Corticosteroid Dose Reduction in Childhood Asthma: Is Nitrosopnea Informative?
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1065 - 1066.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Zacharasiewicz, N. Wilson, C. Lex, E. M. Erin, A. M. Li, T. Hansel, M. Khan, and A. Bush
Clinical Use of Noninvasive Measurements of Airway Inflammation in Steroid Reduction in Children
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1077 - 1082.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005
Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 912 - 930.
[Full Text] [PDF]

Home page
 ThoraxHome page
I Horvath
The exhaled biomarker puzzle: bacteria play their card in the exhaled nitric oxide-exhaled breath condensate nitrite game
Thorax, March 1, 2005; 60(3): 179 - 180.
[Full Text] [PDF]

Home page
 ThoraxHome page
M W Pijnenburg, W Hofhuis, W C Hop, and J C De Jongste
Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission
Thorax, March 1, 2005; 60(3): 215 - 218.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. K. H. Tee and K. P. Hui
Effect of Spirometric Maneuver, Nasal Clip, and Submaximal Inspiratory Effort on Measurement of Exhaled Nitric Oxide Levels in Asthmatic Patients
Chest, January 1, 2005; 127(1): 131 - 134.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G Roberts, C Hurley, A Bush, and G Lack
Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma
Thorax, September 1, 2004; 59(9): 752 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. D. Smith, J. O. Cowan, S. Filsell, C. McLachlan, G. Monti-Sheehan, P. Jackson, and D. R. Taylor
Diagnosing Asthma: Comparisons between Exhaled Nitric Oxide Measurements and Conventional Tests
Am. J. Respir. Crit. Care Med., February 15, 2004; 169(4): 473 - 478.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H.-W. Shin, C. M. Rose-Gottron, D. M. Cooper, R. L. Newcomb, and S. C. George
Airway diffusing capacity of nitric oxide and steroid therapy in asthma
J Appl Physiol, January 1, 2004; 96(1): 65 - 75.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Prieto, L. Bruno, V. Gutierrez, S. Uixera, C. Perez-Frances, A. Lanuza, and A. Ferrer
Airway Responsiveness to Adenosine 5'-Monophosphate and Exhaled Nitric Oxide Measurements: Predictive Value as Markers for Reducing the Dose of Inhaled Corticosteroids in Asthmatic Subjects
Chest, October 1, 2003; 124(4): 1325 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Sandrini, I. M. Ferreira, C. Gutierrez, J. R. Jardim, N. Zamel, and K. R. Chapman
Effect of Montelukast on Exhaled Nitric Oxide and Nonvolatile Markers of Inflammation in Mild Asthma
Chest, October 1, 2003; 124(4): 1334 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S.A. Kharitonov, F. Gonio, C. Kelly, S. Meah, and P.J. Barnes
Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children
Eur. Respir. J., March 1, 2003; 21(3): 433 - 438.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. L. Ren
What Is the Best Way To Measure Lung Function?
Chest, March 1, 2003; 123(3): 667 - 668.
[Full Text] [PDF]

Home page
 ChestHome page
L.-P. Boulet, V. Boulet, and J. Milot
How Should We Quantify Asthma Control?: A Proposal
Chest, December 1, 2002; 122(6): 2217 - 2223.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S.L. Jones, P. Herbison, J.O. Cowan, E.M. Flannery, R.J. Hancox, C.R. McLachlan, and D.R. Taylor
Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship
Eur. Respir. J., September 1, 2002; 20(3): 601 - 608.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. Ghiro, S. Zanconato, O. Rampon, V. Piovan, M.F. Pasquale, and E. Baraldi
Effect of montelukast added to inhaled corticosteroids on fractional exhaled nitric oxide in asthmatic children
Eur. Respir. J., September 1, 2002; 20(3): 630 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Godfrey
Ups and Downs of Nitric Oxide in Chesty Children
Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 438 - 439.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
Members of the Task Force:, E. Baraldi, J.C. de Jongste, B. Gaston, K. Alving, P.J. Barnes, H. Bisgaard, A. Bush, C. Gaultier, H. Grasemann, et al.
Measurement of exhaled nitric oxide in children, 2001: E. Baraldi and J.C. de Jongste on behalf of the Task Force
Eur. Respir. J., July 1, 2002; 20(1): 223 - 237.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Deykin, A. F. Massaro, J. M. Drazen, and E. Israel
Exhaled Nitric Oxide as a Diagnostic Test for Asthma: Online versus Offline Techniques and Effect of Flow Rate
Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1597 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 598 - 618.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. A. Kharitonov and P. J. Barnes
Does Exhaled Nitric Oxide Reflect Asthma Control? . Yes, It Does!
Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 727 - 728.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  ATS Conference