help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van EEDEN, S. F.
Right arrow Articles by HOGG, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van EEDEN, S. F.
Right arrow Articles by HOGG, J. C.

Am. J. Respir. Crit. Care Med., Volume 164, Number 5, September 2001, 826-830

Cytokines Involved in the Systemic Inflammatory Response Induced by Exposure to Particulate Matter Air Pollutants (PM10)

STEPHAN F. van EEDEN, WAN C. TAN, TATSUSHI SUWA, HIROSHI MUKAE, TAKESHI TERASHIMA, TAKESHI FUJII, DIWEN QUI, RENAUD VINCENT, and JAMES C. HOGG

McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada; National University of Singapore, Singapore; and Environmental Health Directorate, Health Canada, Ottawa, Ontario, Canada

Elevated levels of ambient particulate matter (PM10) have been associated with increased cardiopulmonary morbidity and mortality. We previously showed that the deposition of particles in the lung induces a systemic inflammatory response that includes stimulation of the bone marrow. This marrow response is related to mediators released by alveolar macrophages (AM) and in this study we measured cytokines produced by human AM exposed to ambient particles of different composition and size. Identified cytokines were also measured in the circulation of healthy young subjects exposed to air pollutants during the 1997 Southeast Asian forest fires. Human AM were incubated with particle suspensions of residual oil fly ash (ROFA), ambient urban particles (EHC 93), inert carbon particles, and latex particles of different sizes (0.1, 1, and 10 µm) and concentrations for 24 h. Tumor necrosis factor-alpha (TNF-alpha ) increases in a dose-dependent manner when AM were exposed to EHC 93 particles (p < 0.02). The TNF response of AM exposed to different sizes of latex particles was similar. The latex (158 ± 31%), inert carbon (179 ± 32%), and ROFA (216 ± 34%) particles all show a similar maximum TNF response (percent change from baseline) whereas EHC 93 (1,020 ± 212%, p < 0.05) showed a greater maximum response that was similar to lipopolysaccharide (LPS) 1 µg/ml (812 ± 320%). Macrophages incubated with an optimal dose of EHC 93 particles (0.1 mg/ml) also produce a broad spectrum of other proinflammatory cytokines, particularly interleukin (IL)-6 (p < 0.01), IL-1beta (p < 0.05), macrophage inflammatory protein-1alpha (MIP-1alpha ) (p < 0.05), and granulocyte macrophage colony-stimulating factor (GM-CSF) (p < 0.01) with no difference in concentrations of the anti-inflammatory cytokine IL-10 (p = NS). Circulating levels of IL-1beta , IL-6, and GM-CSF were elevated in subjects exposed to high levels of PM10 during an episode of acute air pollution. These results show that a range of different particles stimulate AM to produce proinflammatory cytokines and these cytokines are also present in the blood of subjects during an episode of acute atmospheric air pollution. We postulate that these cytokines induced a systemic response that has an important role in the pathogenesis of the cardiopulmonary adverse health effects associated with atmospheric pollution.

Keywords: air pollution; interleukin-6; granulocyte macrophage colony-stimulating factor; cytokines




This article has been cited by other articles:


Home page
 Toxicol SciHome page
A. I. Totlandsdal, M. Refsnes, T. Skomedal, J.-B. Osnes, P. E. Schwarze, and M. Lag
Particle-Induced Cytokine Responses in Cardiac Cell Cultures--the Effect of Particles versus Soluble Mediators Released by Particle-Exposed Lung Cells
Toxicol. Sci., November 1, 2008; 106(1): 233 - 241.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
M S Goldberg, N Giannetti, R T Burnett, N E Mayo, M-F Valois, and J M Brophy
A panel study in congestive heart failure to estimate the short-term effects from personal factors and environmental conditions on oxygen saturation and pulse rate
Occup. Environ. Med., October 1, 2008; 65(10): 659 - 666.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. L. Rouse, G. Murphy, M. J. Boudreaux, D. B. Paulsen, and A. L. Penn
Soot Nanoparticles Promote Biotransformation, Oxidative Stress, and Inflammation in Murine Lungs
Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 198 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. R. Swiston, W. Davidson, S. Attridge, G. T. Li, M. Brauer, and S. F. van Eeden
Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters
Eur. Respir. J., July 1, 2008; 32(1): 129 - 138.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
F. M. Arantes-Costa, F. D.T.Q.S. Lopes, A. C. Toledo, P. A. Magliarelli-Filho, H. T. Moriya, R. Carvalho-Oliveira, T. Mauad, P. H. N. Saldiva, and M. A. Martins
Effects of Residual Oil Fly Ash (ROFA) in Mice with Chronic Allergic Pulmonary Inflammation
Toxicol Pathol, July 1, 2008; 36(5): 680 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Tamagawa, N. Bai, K. Morimoto, C. Gray, T. Mui, K. Yatera, X. Zhang, L. Xing, Y. Li, I. Laher, et al.
Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction
Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L79 - L85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Yatera, J. Hsieh, J. C. Hogg, E. Tranfield, H. Suzuki, C.-H. Shih, A. R. Behzad, R. Vincent, and S. F. van Eeden
Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H944 - H953.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. C. Gonzalez, J. Allen, V. G. Blanco, E. J. Schmidt, N. van Rooijen, and J. G. Wood
Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia
J Appl Physiol, October 1, 2007; 103(4): 1386 - 1394.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
L. Calderon-Garciduenas, M. Franco-Lira, R. Torres-Jardon, C. Henriquez-Roldan, G. Barragan-Mejia, G. Valencia-Salazar, A. Gonzalez-Maciel, R. Reynoso-Robles, R. Villarreal-Calderon, and W. Reed
Pediatric Respiratory and Systemic Effects of Chronic Air Pollution Exposure: Nose, Lung, Heart, and Brain Pathology
Toxicol Pathol, January 1, 2007; 35(1): 154 - 162.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
M.-H. Cha, T. Rhim, K. H. Kim, A.-S. Jang, Y.-K. Paik, and C.-S. Park
Proteomic Identification of Macrophage Migration-inhibitory Factor upon Exposure to TiO2 Particles
Mol. Cell. Proteomics, January 1, 2007; 6(1): 56 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. A. Ritz, J. Wan, and D. Diaz-Sanchez
Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract
Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L33 - L39.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Maitre, V. Bonneterre, L. Huillard, P. Sabatier, and R. de Gaudemaris
Impact of urban atmospheric pollution on coronary disease
Eur. Heart J., October 1, 2006; 27(19): 2275 - 2284.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
A. Zeka, J. R Sullivan, P. S Vokonas, D. Sparrow, and J. Schwartz
Inflammatory markers and particulate air pollution: characterizing the pathway to disease
Int. J. Epidemiol., October 1, 2006; 35(5): 1347 - 1354.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Bhatnagar
Environmental Cardiology: Studying Mechanistic Links Between Pollution and Heart Disease
Circ. Res., September 29, 2006; 99(7): 692 - 705.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Aronson, I. Roterman, M. Yigla, A. Kerner, O. Avizohar, R. Sella, P. Bartha, Y. Levy, and W. Markiewicz
Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects
Am. J. Respir. Crit. Care Med., September 15, 2006; 174(6): 626 - 632.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
A. V. Diez Roux, A. H. Auchincloss, B. Astor, R. G. Barr, M. Cushman, T. Dvonch, D. R. Jacobs Jr., J. Kaufman, X. Lin, and P. Samson
Recent Exposure to Particulate Matter and C-reactive Protein Concentration in the Multi-Ethnic Study of Atherosclerosis
Am. J. Epidemiol., September 1, 2006; 164(5): 437 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Cozzi, S. Hazarika, H. W. Stallings III, W. E. Cascio, R. B. Devlin, R. M. Lust, C. J. Wingard, and M. R. Van Scott
Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice
Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H894 - H903.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
C. Chen, M. Arjomandi, H. Qin, J. Balmes, I. Tager, and N. Holland
Cytogenetic damage in buccal epithelia and peripheral lymphocytes of young healthy individuals exposed to ozone
Mutagenesis, March 1, 2006; 21(2): 131 - 137.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
Q. Sun, A. Wang, X. Jin, A. Natanzon, D. Duquaine, R. D. Brook, J.-G. S. Aguinaldo, Z. A. Fayad, V. Fuster, M. Lippmann, et al.
Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model
JAMA, December 21, 2005; 294(23): 3003 - 3010.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Schwartz, S. K. Park, M. S. O'Neill, P. S. Vokonas, D. Sparrow, S. Weiss, and K. Kelsey
Glutathione-S-Transferase M1, Obesity, Statins, and Autonomic Effects of Particles: Gene-by-Drug-by-Environment Interaction
Am. J. Respir. Crit. Care Med., December 15, 2005; 172(12): 1529 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
Y. Tesfaigzi, J. D. McDonald, M. D. Reed, S. P. Singh, G. T. De Sanctis, P. R. Eynott, F. F. Hahn, M. J. Campen, and J. L. Mauderly
Low-Level Subchronic Exposure to Wood Smoke Exacerbates Inflammatory Responses in Allergic Rats
Toxicol. Sci., December 1, 2005; 88(2): 505 - 513.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
A Zeka, A Zanobetti, and J Schwartz
Short term effects of particulate matter on cause specific mortality: effects of lags and modification by city characteristics
Occup. Environ. Med., October 1, 2005; 62(10): 718 - 725.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
H.-Y. Cho, A. E. Jedlicka, R. Clarke, and S. R. Kleeberger
Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash
Physiol Genomics, June 16, 2005; 22(1): 108 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. F. van Eeden, A. Yeung, K. Quinlam, and J. C. Hogg
Systemic Response to Ambient Particulate Matter: Relevance to Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 61 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. I. Rennard
Clinical Approach to Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease
Proceedings of the ATS, April 1, 2005; 2(1): 94 - 100.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
W. Q. Gan, S.F. P. Man, and D. D. Sin
The Interactions Between Cigarette Smoking and Reduced Lung Function on Systemic Inflammation
Chest, February 1, 2005; 127(2): 558 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Goto, H. Ishii, J. C. Hogg, C.-H. Shih, K. Yatera, R. Vincent, and S. F. van Eeden
Particulate Matter Air Pollution Stimulates Monocyte Release from the Bone Marrow
Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 891 - 897.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
F. Gao, A. Barchowsky, A. A. Nemec, and J. P. Fabisiak
Microbial Stimulation by Mycoplasma fermentans Synergistically Amplifies IL-6 Release by Human Lung Fibroblasts in Response to Residual Oil Fly Ash (ROFA) and Nickel
Toxicol. Sci., October 1, 2004; 81(2): 467 - 479.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. W. Hollingsworth II, D. N. Cook, D. M. Brass, J. K. L. Walker, D. L. Morgan, W. M. Foster, and D. A. Schwartz
The Role of Toll-like Receptor 4 in Environmental Airway Injury in Mice
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 126 - 132.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
W Q Gan, S F P Man, A Senthilselvan, and D D Sin
Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
Thorax, July 1, 2004; 59(7): 574 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Goto, J. C. Hogg, C.-H. Shih, H. Ishii, R. Vincent, and S. F. van Eeden
Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L79 - L85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Ishii, T. Fujii, J. C. Hogg, S. Hayashi, H. Mukae, R. Vincent, and S. F. van Eeden
Contribution of IL-1{beta} and TNF-{alpha} to the initiation of the peripheral lung response to atmospheric particulates (PM10)
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L176 - L183.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. D. Brook, B. Franklin, W. Cascio, Y. Hong, G. Howard, M. Lipsett, R. Luepker, M. Mittleman, J. Samet, S. C. Smith Jr, et al.
Air Pollution and Cardiovascular Disease: A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association
Circulation, June 1, 2004; 109(21): 2655 - 2671.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. Campa, S. Zienolddiny, V. Maggini, V. Skaug, A. Haugen, and F. Canzian
Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer
Carcinogenesis, February 1, 2004; 25(2): 229 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Bhatnagar
Cardiovascular pathophysiology of environmental pollutants
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H479 - H485.
[Full Text] [PDF]

Home page
 CirculationHome page
C. A. Pope III, R. T. Burnett, G. D. Thurston, M. J. Thun, E. E. Calle, D. Krewski, and J. J. Godleski
Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease
Circulation, January 6, 2004; 109(1): 71 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
V. Mishra
Indoor air pollution from biomass combustion and acute respiratory illness in preschool age children in Zimbabwe
Int. J. Epidemiol., October 1, 2003; 32(5): 847 - 853.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Goto, J. C. Hogg, T. Suwa, K. B. Quinlan, and S. F. van Eeden
A novel method to quantify the turnover and release of monocytes from the bone marrow using the thymidine analog 5'-bromo-2'-deoxyuridine
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C253 - C259.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A.G.N. Agusti, A. Noguera, J. Sauleda, E. Sala, J. Pons, and X. Busquets
Systemic effects of chronic obstructive pulmonary disease
Eur. Respir. J., February 1, 2003; 21(2): 347 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Fujii, J. C. Hogg, N. Keicho, R. Vincent, S. F. Van Eeden, and S. Hayashi
Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10
Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L290 - L297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. Tobin
Compliance (COMmunicate PLease wIth Less Abbreviations, Noun Clusters, and Exclusiveness)
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1534 - 1536.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Fujii, S. Hayashi, J. C. Hogg, H. Mukae, T. Suwa, Y. Goto, R. Vincent, and S. F. van Eeden
Interaction of Alveolar Macrophages and Airway Epithelial Cells Following Exposure to Particulate Matter Produces Mediators that Stimulate the Bone Marrow
Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 34 - 41.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. Suwa, J. C. Hogg, K. B. Quinlan, A. Ohgami, R. Vincent, and S. F. van Eeden
Particulate air pollution induces progression of atherosclerosis
J. Am. Coll. Cardiol., March 20, 2002; 39(6): 935 - 942.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Chronic Obstructive Pulmonary Disease, Pollution, Pulmonary Vascular Disease, Transplantation, Pleural Disease, and Lung Cancer in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 642 - 662.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  ATS State of the Art 2009