This Article Full Text Full Text (PDF) All Versions of this Article: 200404-465SOv1 200404-465SOv2 200404-465SOv3 172/6/660    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Morse, D. Articles by Choi, A. M. K. Search for Related Content PubMed PubMed Citation Articles by Morse, D. Articles by Choi, A. M. K.

Heme Oxygenase-1

From Bench to Bedside

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania

Correspondence and requests for reprints should be addressed to Danielle Morse, M.D., NW 628 UPMC Montefiore, 3459 Fifth Avenue, Pittsburgh, PA 15213. E-mail: morseed{at}upmc.edu

As aspects of basic science come to play an increasingly prominent role in clinical medicine, heme oxygenase-1 is one of several molecules emerging as a central player in diseases of the lung and intensive care unit. Although the apparent raison d'être of this enzyme is to dispose of heme, its activity results in cytoprotection against oxidative injury and cellular stresses. As the lung interfaces directly with an oxidizing environment, it is expected that heme oxygenase-1 would be involved in many aspects of lung health and disease. The protective effects of heme oxygenase-1 and products of its enzymatic activity, including carbon monoxide, biliverdin and bilirubin, and ferritin, have opened the door to potential therapeutic and disease-monitoring possibilities that one day may be applicable to pulmonary medicine. This article introduces readers to the history of heme oxygenase research, the role of this enzyme in the lung, and related new developments to look forward to in the fields of pulmonary and critical care medicine.

Key Words: carbon monoxide • heme oxygenase-1 • lung • nitric oxide

This article has been cited by other articles:

				S. Lee, R. Li, B. Kim, R. Palvolgyi, T. Ho, Q.-Z. Yang, J. Xu, W. L. Szeto, H. Honda, and J. A. Berliner Ox-PAPC activation of PMET system increases expression of heme oxygenase-1 in human aortic endothelial cell J. Lipid Res., February 1, 2009; 50(2): 265 - 274. [Abstract] [Full Text] [PDF]

				R. L. Owens, S. Yim-Yeh, and A. Malhotra Carbon Monoxide Poisoning, or Carbon Monoxide Protection? Chest, November 1, 2008; 134(5): 895 - 896. [Full Text] [PDF]

				Y. Jin, H. P. Kim, M. Chi, E. Ifedigbo, S. W. Ryter, and A. M. K. Choi Deletion of Caveolin-1 Protects against Oxidative Lung Injury via Up-Regulation of Heme Oxygenase-1 Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 171 - 179. [Abstract] [Full Text] [PDF]

				Q. Ye, Y. Dalavanga, N. Poulakis, S. U. Sixt, J. Guzman, and U. Costabel Decreased expression of haem oxygenase-1 by alveolar macrophages in idiopathic pulmonary fibrosis Eur. Respir. J., May 1, 2008; 31(5): 1030 - 1036. [Abstract] [Full Text] [PDF]

				N. G. Abraham and A. Kappas Pharmacological and Clinical Aspects of Heme Oxygenase Pharmacol. Rev., March 1, 2008; 60(1): 79 - 127. [Abstract] [Full Text] [PDF]

				S. A. Nonas, L. M. Vinasco, S. F. Ma, J. R. Jacobson, A. A. Desai, S. M. Dudek, C. Flores, P. M. Hassoun, L. Sam, S. Q. Ye, et al. Use of consomic rats for genomic insights into ventilator-associated lung injury Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L292 - L302. [Abstract] [Full Text] [PDF]

				A. C. Burman, T. Banovic, R. D. Kuns, A. D. Clouston, A. C. Stanley, E. S. Morris, V. Rowe, H. Bofinger, R. Skoczylas, N. Raffelt, et al. IFN{gamma} differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract Blood, August 1, 2007; 110(3): 1064 - 1072. [Abstract] [Full Text] [PDF]

				T. S. Nawrot, A. Nemmar, and B. Nemery Update in Environmental and Occupational Medicine 2006 Am. J. Respir. Crit. Care Med., April 15, 2007; 175(8): 758 - 762. [Full Text] [PDF]

				D.-J. Slebos, S. W. Ryter, M. van der Toorn, F. Liu, F. Guo, C. J. Baty, J. M. Karlsson, S. C. Watkins, H. P. Kim, X. Wang, et al. Mitochondrial Localization and Function of Heme Oxygenase-1 in Cigarette Smoke-Induced Cell Death Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 409 - 417. [Abstract] [Full Text] [PDF]

				D. J. Funk and A. S. Clay A 29-Year-Old Woman With Sudden Anemia and Arterial Oxygen Desaturation Chest, February 1, 2007; 131(2): 621 - 623. [Full Text] [PDF]

				T. Sato, M. Takeno, K. Honma, H. Yamauchi, Y. Saito, T. Sasaki, H. Morikubo, Y. Nagashima, S. Takagi, K. Yamanaka, et al. Heme Oxygenase-1, a Potential Biomarker of Chronic Silicosis, Attenuates Silica-induced Lung Injury Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 906 - 914. [Abstract] [Full Text] [PDF]

				A Guenegou, B Leynaert, J Benessiano, I Pin, P Demoly, F Neukirch, J Boczkowski, and M Aubier Association of lung function decline with the heme oxygenase-1 gene promoter microsatellite polymorphism in a general population sample. Results from the European Community Respiratory Health Survey (ECRHS), France. J. Med. Genet., August 1, 2006; 43(8): e43 - e43. [Abstract] [Full Text] [PDF]

				E. B. Milbrandt, A. Ishizaka, and D. C. Angus Update in critical care 2005. Am. J. Respir. Crit. Care Med., April 15, 2006; 173(8): 833 - 841. [Full Text] [PDF]

				H. Morimatsu, T. Takahashi, K. Maeshima, K. Inoue, T. Kawakami, H. Shimizu, M. Takeuchi, M. Yokoyama, H. Katayama, and K. Morita Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IX{alpha} concentrations Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L114 - L119. [Abstract] [Full Text] [PDF]