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Contents: Volume 161, Issue 5; May 1, 2000   [Index by Author] 
       EDITORIALS
       PRO/CON EDITORIALS
       HOW IT REALLY HAPPENED
       UPDATE IN NONPULMONARY CRITICAL CARE
       STATE OF THE ART
       Airway Biology, Asthma, and Chronic Obstructive Pulmonary Disease
       Fibrotic Disorders and Lung Infection
       Mechanical Ventilation and Acute Lung Injury
       Pediatric Pulmonary Disease
       Sleep-Disordered Breathing
       ATS/ERS WORKSHOP SUMMARY
       CORRESPONDENCE
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EDITORIALS:

Jonathan M. Samet, F. Javier Nieto, and Naresh M. Punjabi
Sleep-disordered Breathing and Hypertension: More Research Is Still Needed
Am. J. Respir. Crit. Care Med. 2000; 161: 1409-1411. [Full text]  


PRO/CON EDITORIALS:

Christian Guilleminault and Susmita Chowdhuri
Upper Airway Resistance Syndrome Is a Distinct Syndrome
Am. J. Respir. Crit. Care Med. 2000; 161: 1412-1413. [Full text]  

Neil J. Douglas
Upper Airway Resistance Syndrome Is Not a Distinct Syndrome
Am. J. Respir. Crit. Care Med. 2000; 161: 1413-1415. [Full text]  

REBUTTAL FROM DRS. GUILLEMINAULT AND CHOWDHURI
Am. J. Respir. Crit. Care Med. 2000; 161: 1415a. [Full text]  

REBUTTAL FROM DR. DOUGLAS
Am. J. Respir. Crit. Care Med. 2000; 161: 1415b-1416. [Full text]  


HOW IT REALLY HAPPENED:

ROBERT E. FORSTER, II
How Science Happened to Me
Am. J. Respir. Crit. Care Med. 2000; 161: 1421-1422. [Full text]  


UPDATE IN NONPULMONARY CRITICAL CARE:

DANIEL S. PRATT and SCOTT K. EPSTEIN
Recent Advances in Critical Care Gastroenterology
Am. J. Respir. Crit. Care Med. 2000; 161: 1417-1420. [Full text]  


STATE OF THE ART:

JEAN BOUSQUET, PETER K. JEFFERY, WILLIAM W. BUSSE, MALCOLM JOHNSON, and ANTONIO M. VIGNOLA
Asthma . From Bronchoconstriction to Airways Inflammation and Remodeling
Am. J. Respir. Crit. Care Med. 2000; 161: 1720-1745. [Full text]  


ARTICLES:

Airway Biology, Asthma, and Chronic Obstructive Pulmonary Disease:

ANTHONY A. FRYER, ANDREA BIANCO, MICHAEL HEPPLE, PETER W. JONES, RICHARD C. STRANGE, and MONICA A. SPITERI
Polymorphism at the Glutathione S-transferase GSTP1 Locus . A New Marker for Bronchial Hyperresponsiveness and Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 1437-1442. [Abstract] [Full text]  

RUTH E. ALDRIDGE, ROBERT J. HANCOX, D. ROBIN TAYLOR, JAN O. COWAN, MARTI C. WINN, CHRIS M. FRAMPTON, and G. IAN TOWN
Effects of Terbutaline and Budesonide on Sputum Cells and Bronchial Hyperresponsiveness In Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 1459-1464. [Abstract] [Full text]  

GAIL M. GAUVREAU, JONG M. LEE, RICHARD M. WATSON, ANNE-MARIE A. IRANI, LAWRENCE B. SCHWARTZ, and PAUL M. O'BYRNE
Increased Numbers of Both Airway Basophils and Mast Cells in Sputum after Allergen Inhalation Challenge of Atopic Asthmatics
Am. J. Respir. Crit. Care Med. 2000; 161: 1473-1478. [Abstract] [Full text]  

JEAN-BRUNO LANGDEAU, HÉLÈNE TURCOTTE, DENNIS M. BOWIE, JEAN JOBIN, PIERRE DESGAGNÉ, and LOUIS-PHILIPPE BOULET
Airway Hyperresponsiveness in Elite Athletes
Am. J. Respir. Crit. Care Med. 2000; 161: 1479-1484. [Abstract] [Full text]  

EDUARD MONSÓ, JEAN-LUC MALO, CLAIRE INFANTE-RIVARD, HEBERTO GHEZZO, MICHÈLE MAGNAN, JOCELYNE L'ARCHEVÈQUE, CAROLE TRUDEAU, and DENYSE GAUTRIN
Individual Characteristics and Quitting in Apprentices Exposed to High-molecular-weight Agents
Am. J. Respir. Crit. Care Med. 2000; 161: 1508-1512. [Abstract] [Full text]  

DON D. SIN and JACK V. TU
Are Elderly Patients with Obstructive Airway Disease Being Prematurely Discharged?
Am. J. Respir. Crit. Care Med. 2000; 161: 1513-1517. [Abstract] [Full text]  

TRACEY D. ROBINSON, DAVID B. FREIBERG, JEFF A. REGNIS, and IVEN H. YOUNG
The Role of Hypoventilation and Ventilation-Perfusion Redistribution in Oxygen-induced Hypercapnia during Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 1524-1529. [Abstract] [Full text]  

ALISON J. MACFARLANE, RYSZARD DWORSKI, JAMES R. SHELLER, IAN D. PAVORD, A. BARRY KAY, and NEIL C. BARNES
Sputum Cysteinyl Leukotrienes Increase 24 Hours after Allergen Inhalation in Atopic Asthmatics
Am. J. Respir. Crit. Care Med. 2000; 161: 1553-1558. [Abstract] [Full text]  

TERENCE A. R. SEEMUNGAL, GAVIN C. DONALDSON, ANGSHU BHOWMIK, DONALD J. JEFFRIES, and JADWIGA A. WEDZICHA
Time Course and Recovery of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 1608-1613. [Abstract] [Full text]  

WAYNE MITZNER and ROBERT H. BROWN
Potential Mechanism of Hyperresponsive Airways
Am. J. Respir. Crit. Care Med. 2000; 161: 1619-1623. [Abstract] [Full text]  

ALVIN M. SANICO, ANDRZEJ M. STANISZ, TODD D. GLEESON, SUSAN BORA, DAVID PROUD, JOHN BIENENSTOCK, VASSILIS E. KOLIATSOS, and ALKIS TOGIAS
Nerve Growth Factor Expression and Release in Allergic Inflammatory Disease of the Upper Airways
Am. J. Respir. Crit. Care Med. 2000; 161: 1631-1635. [Abstract] [Full text]  

TAKESHI SHIMIZU, HITOMI HIRANO, YUICHI MAJIMA, and YASUO SAKAKURA
A Mechanism of Antigen-induced Mucus Production in Nasal Epithelium of Sensitized Rats . A Comparison with Lipopolysaccharide-induced Mucus Production
Am. J. Respir. Crit. Care Med. 2000; 161: 1648-1654. [Abstract] [Full text]  

GERT FOLKERTS, JANNEKE WESTRA-de VLIEGER, ANNICK de VRIES, STEPHAN FAAS, HENK van der LINDE, FERDI ENGELS, JAN C. de JONG, FONS A. K. C. P. VERHEYEN, DICKY VAN HEUVEN-NOLSEN, and FRANS P. NIJKAMP
Virus- and Bradykinin-Induced Airway Hyperresponsiveness in Guinea Pigs
Am. J. Respir. Crit. Care Med. 2000; 161: 1666-1671. [Abstract] [Full text]  

FABIO L. M. RICCIARDOLO, MARTIN STEINHOFF, SILVIA AMADESI, REMO GUERRINI, MICHELE TOGNETTO, MARCELLO TREVISANI, CHRISTOPHE CREMINON, CLAUDE BERTRAND, NIGEL W. BUNNETT, LEONARDO M. FABBRI, SEVERO SALVADORI, and PIERANGELO GEPPETTI
Presence and Bronchomotor Activity of Protease-Activated Receptor-2 in Guinea Pig Airways
Am. J. Respir. Crit. Care Med. 2000; 161: 1672-1680. [Abstract] [Full text]  


Fibrotic Disorders and Lung Infection:

JOHN R. WARREN, MONDIRA BHATTACHARYA, KLEPER N. F. DE ALMEIDA, KATHY TRAKAS, and LANCE R. PETERSON
A Minimum 5.0 ml of Sputum Improves the Sensitivity of Acid-fast Smear for Mycobacterium tuberculosis
Am. J. Respir. Crit. Care Med. 2000; 161: 1559-1562. [Abstract] [Full text]  

NATHALIE DANIEL, NACER LOUNIS, BAOHONG JI, RICHARD J. O'BRIEN, ANDREW VERNON, LAWRENCE J. GEITER, MICHEL SZPYTMA, CHANTAL TRUFFOT-PERNOT, GILLES HEJBLUM, and JACQUES GROSSET
Antituberculosis Activity of Once-weekly Rifapentine-containing Regimens in Mice . Long-term Effectiveness with 6- and 8-Month Treatment Regimens
Am. J. Respir. Crit. Care Med. 2000; 161: 1572-1577. [Abstract] [Full text]  

KENJI TANI, FUMITAKA OGUSHI, LUPING HUANG, TETSUYA KAWANO, HIROYA TADA, NORIMITSU HARIGUCHI, and SABURO SONE
CD13/aminopeptidase N, a Novel Chemoattractant for T Lymphocytes in Pulmonary Sarcoidosis
Am. J. Respir. Crit. Care Med. 2000; 161: 1636-1642. [Abstract] [Full text]  

EISAKU TANAKA, TERUMI KIMOTO, HISAKO MATSUMOTO, KAZUNARI TSUYUGUCHI, KATSUHIRO SUZUKI, SONOKO NAGAI, MITSUNOBU SHIMADZU, HIDEAKI ISHIBATAKE, TAKAKO MURAYAMA, and RYOICHI AMITANI
Familial Pulmonary Mycobacterium avium Complex Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 1643-1647. [Abstract] [Full text]  

NAGATO SATO, YUKIO SUZUKI, KAZUMI NISHIO, KOICHI SUZUKI, KATSUHIKO NAOKI, KEI TAKESHITA, HIROYASU KUDO, NAOKI MIYAO, HARUKUNI TSUMURA, HIROSHI SERIZAWA, MAKOTO SUEMATSU, and KAZUHIRO YAMAGUCHI
Roles of ICAM-1 for Abnormal Leukocyte Recruitment in the Microcirculation of Bleomycin-induced Fibrotic Lung Injury
Am. J. Respir. Crit. Care Med. 2000; 161: 1681-1688. [Abstract] [Full text]  

LI-HUA PAN, KOHEI YAMAUCHI, TAKASHI SAWAI, TOSHIHIDE NAKADATE, YUKI KOJIMA, NAOFUMI TAKAHASHI, KEISUKE ADACHI, AKIHIKO KAMEYAMA, and HIROSHI INOUE
Inhibition of Binding of E- and P-selectin to Sialyl-Lewis X Molecule Suppresses the Inflammatory Response in Hypersensitivity Pneumonitis in Mice
Am. J. Respir. Crit. Care Med. 2000; 161: 1689-1697. [Abstract] [Full text]  

ANNIE PARDO, ROBERTO BARRIOS, MIGUEL GAXIOLA, LOURDES SEGURA-VALDEZ, GUILLERMO CARRILLO, ANDREA ESTRADA, MAYRA MEJÍA, and MOISÉS SELMAN
Increase of Lung Neutrophils in Hypersensitivity Pneumonitis Is Associated with Lung Fibrosis
Am. J. Respir. Crit. Care Med. 2000; 161: 1698-1704. [Abstract] [Full text]  

EDWARD D. CHAN, RANDALL REVES, JOHN T. BELISLE, PATRICK J. BRENNAN, and WILLIAM E. HAHN
Diagnosis of Tuberculosis by a Visually Detectable Immunoassay for Lipoarabinomannan
Am. J. Respir. Crit. Care Med. 2000; 161: 1713-1719. [Abstract] [Full text]  

WEI-YU LIAO, YUANG-SHUANG LIAW, HAO-CHIEN WANG, KUAN-YU CHEN, KWEN-TAY LUH, and PAN-CHYR YANG
Bacteriology of Infected Cavitating Lung Tumor
Am. J. Respir. Crit. Care Med. 2000; 161: 1750-1753. [Abstract] [Full text]  


Mechanical Ventilation and Acute Lung Injury:

RINALDO BELLOMO, JOHN A. KELLUM, CHANDRASHEKHAR R. GANDHI, MICHAEL R. PINSKY, and Brian Ondulik
The Effect of Intensive Plasma Water Exchange by Hemofiltration on Hemodynamics and Soluble Mediators in Canine Endotoxemia
Am. J. Respir. Crit. Care Med. 2000; 161: 1429-1436. [Abstract] [Full text]  

JEFFERY CHRISTENSON, ANNICK LAVOIE, MICHAEL O'CONNOR, SANGEETA BHORADE, ANNE POHLMAN, and JESSE B. HALL
The Incidence and Pathogenesis of Cardiopulmonary Deterioration after Abrupt Withdrawal of Inhaled Nitric Oxide
Am. J. Respir. Crit. Care Med. 2000; 161: 1443-1449. [Abstract] [Full text]  

ANDRÉS ESTEBAN, ANTONIO ANZUETO, INMACULADA ALÍA, FEDERICO GORDO, CARLOS APEZTEGUÍA, FERNANDO PÁLIZAS, DAVID CIDE, ROSANNE GOLDWASER, LUIS SOTO, GUILLERMO BUGEDO, CARLOS RODRIGO, JORGE PIMENTEL, GUILLERMO RAIMONDI, and MARTIN J. TOBIN
How Is Mechanical Ventilation Employed in the Intensive Care Unit? . An International Utilization Review
Am. J. Respir. Crit. Care Med. 2000; 161: 1450-1458. [Abstract] [Full text]  

THOMAS E.VAN der  KLOOT, LLUIS BLANCH, A. MELYNNE YOUNGBLOOD, CRAIG WEINERT, ALEX B. ADAMS, JOHN J. MARINI, ROBERT S. SHAPIRO, and AVI NAHUM
Recruitment Maneuvers in Three Experimental Models of Acute Lung Injury . Effect on Lung Volume and Gas Exchange
Am. J. Respir. Crit. Care Med. 2000; 161: 1485-1494. [Abstract] [Full text]  

DIETRICH HÄFNER and PAUL-GEORG GERMANN
Additive Effects of Phosphodiesterase-4 Inhibition on Effects of rSP-C Surfactant
Am. J. Respir. Crit. Care Med. 2000; 161: 1495-1500. [Abstract] [Full text]  

WILLIAM M. COPLIN, DAVID J. PIERSON, KATHY D. COOLEY, DAVID W. NEWELL, and GORDON D. RUBENFELD
Implications of Extubation Delay in Brain-Injured Patients Meeting Standard Weaning Criteria
Am. J. Respir. Crit. Care Med. 2000; 161: 1530-1536. [Abstract] [Full text]  

PETER NEUMANN, JAN E. BERGLUND, LARS G. ANDERSSON, ENN MARIPU, ANDERS MAGNUSSON, and GÖRAN HEDENSTIERNA
Effects of Inverse Ratio Ventilation and Positive End-Expiratory Pressure in Oleic Acid-Induced Lung Injury
Am. J. Respir. Crit. Care Med. 2000; 161: 1537-1545. [Abstract] [Full text]  

ANDREA ALIVERTI, RAFFAELE DELLACÁ, PAOLO PELOSI, DAVIDE CHIUMELLO, ANTONIO PEDOTTI, and LUCIANO GATTINONI
Optoelectronic Plethysmography in Intensive Care Patients
Am. J. Respir. Crit. Care Med. 2000; 161: 1546-1552. [Abstract] [Full text]  

ANTONIA KOUTSOUKOU, APOSTOLOS ARMAGANIDIS, CRISTIE STAVRAKAKI-KALLERGI, THEODOROS VASSILAKOPOULOS, ANDREAS LYMBERIS, CHARIS ROUSSOS, and JOSEPH MILIC-EMILI
Expiratory Flow Limitation and Intrinsic Positive End-Expiratory Pressure at Zero Positive End-Expiratory Pressure in Patients with Adult Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med. 2000; 161: 1590-1596. [Abstract] [Full text]  

ANTOINE VIEILLARD-BARON, EMMANUELLE GIROU, ELISABETH VALENTE, CHRISTIAN BRUN-BUISSON, FRANÇOIS JARDIN, FRANÇOIS LEMAIRE, and LAURENT BROCHARD
Predictors of Mortality in Acute Respiratory Distress Syndrome . Focus on the Role of Right Heart Catheterization
Am. J. Respir. Crit. Care Med. 2000; 161: 1597-1601. [Abstract] [Full text]  

LINDA A. KIRSCHENBAUM, MOHAMMED AZIZ, MARK E. ASTIZ, DHANONJOY C. SAHA, and ERIC C. RACKOW
Influence of Rheologic Changes and Platelet-Neutrophil Interactions on Cell Filtration in Sepsis
Am. J. Respir. Crit. Care Med. 2000; 161: 1602-1607. [Abstract] [Full text]  

CARLOS F. LANGE and WARREN H. FINLAY
Overcoming the Adverse Effect of Humidity in Aerosol Delivery via Pressurized Metered-Dose Inhalers during Mechanical Ventilation
Am. J. Respir. Crit. Care Med. 2000; 161: 1614-1618. [Abstract] [Full text]  

KARIM ARSALANE, FABRICE BROECKAERT, BERNARD KNOOPS, MURIELLE WIEDIG, GERARD TOUBEAU, and ALFRED BERNARD
Clara Cell Specific Protein (CC16) Expression after Acute Lung Inflammation Induced by Intratracheal Lipopolysaccharide Administration
Am. J. Respir. Crit. Care Med. 2000; 161: 1624-1630. [Abstract] [Full text]  

RICHARD K. ALBERT and ROLF D. HUBMAYR
The Prone Position Eliminates Compression of the Lungs by the Heart
Am. J. Respir. Crit. Care Med. 2000; 161: 1660-1665. [Abstract] [Full text]  

ELLIOTT D. CROUSER, MARK W. JULIAN, DAVID M. WEINSTEIN, RUAIRI J. FAHY, and JOHN A. BAUER
Endotoxin-induced Ileal Mucosal Injury and Nitric Oxide Dysregulation Are Temporally Dissociated
Am. J. Respir. Crit. Care Med. 2000; 161: 1705-1712. [Abstract] [Full text]  


Pediatric Pulmonary Disease:

NELE SIGURS, RAGNAR BJARNASON, FRIDRIK SIGURBERGSSON, and BENGT KJELLMAN
Respiratory Syncytial Virus Bronchiolitis in Infancy Is an Important Risk Factor for Asthma and Allergy at Age 7 
Am. J. Respir. Crit. Care Med. 2000; 161: 1501-1507. [Abstract] [Full text]  

LOUIS BONT, COBI J. HEIJNEN, ANNEMIEKE KAVELAARS, WIM M. C. van AALDEREN, FRANK BRUS, JOS Th. M. DRAAISMA, SIBYL M. GEELEN, and JAN L. L. KIMPEN
Monocyte IL-10 Production during Respiratory Syncytial Virus Bronchiolitis Is Associated with Recurrent Wheezing in a One-Year Follow-up Study
Am. J. Respir. Crit. Care Med. 2000; 161: 1518-1523. [Abstract] [Full text]  

PIERRE ERNST and YVON CORMIER
Relative Scarcity of Asthma and Atopy among Rural Adolescents Raised on a Farm
Am. J. Respir. Crit. Care Med. 2000; 161: 1563-1566. [Abstract] [Full text]  

ARNOLD C. G. PLATZKER, ANDREW A. COLIN, XIN C. CHEN, PETER HIATT, JANICE HUNTER, ANATASSIOS C. KOUMBOURLIS, MARK D. SCHLUCHTER, ANDREW TING, and MARY ELLEN WOHL
Thoracoabdominal Compression and Respiratory System Compliance in HIV-infected Infants
Am. J. Respir. Crit. Care Med. 2000; 161: 1567-1571. [Abstract] [Full text]  

DENNIS R. OWNBY, EDWARD L. PETERSON, and CHRISTINE C. JOHNSON
Factors Related to Methacholine Airway Responsiveness in Children
Am. J. Respir. Crit. Care Med. 2000; 161: 1578-1583. [Abstract] [Full text]  

MIRKA TORRESIN, LUC J. I. ZIMMERMANN, PAOLA E. COGO, PAOLA CAVICCHIOLI, TAMARA BADON, GIUSEPPE GIORDANO, FRANCO ZACCHELLO, PIETER J. J. SAUER, and VIRGILIO P. CARNIELLI
Exogenous Surfactant Kinetics in Infant Respiratory Distress Syndrome: A Novel Method with Stable Isotopes
Am. J. Respir. Crit. Care Med. 2000; 161: 1584-1589. [Abstract] [Full text]  

SHOUKANG ZHU, MOIRA CHAN-YEUNG, ALLAN B. BECKER, HELEN DIMICH-WARD, ALEXANDER C. FERGUSON, JURE MANFREDA, WADE T. A. WATSON, PETER D. PARÉ, and ANDREW J. SANDFORD
Polymorphisms of the IL-4, TNF-alpha , and Fcalpha RIbeta Genes and the Risk of Allergic Disorders in At-risk Infants
Am. J. Respir. Crit. Care Med. 2000; 161: 1655-1659. [Abstract] [Full text]  

PIERRE-HENRI JARREAU, BRUNO LOUIS, LUC DESFRÈRE, PIERRE W. BLANCHARD, DANIEL ISABEY, ALAIN HARF, and GUY MORIETTE
Detection of Positional Airway Obstruction in Neonates by Acoustic Reflection
Am. J. Respir. Crit. Care Med. 2000; 161: 1754-1756. [Abstract] [Full text]  

PETER FRANKLIN, PETER DINGLE, and STEPHEN STICK
Raised Exhaled Nitric Oxide in Healthy Children Is Associated with Domestic Formaldehyde Levels
Am. J. Respir. Crit. Care Med. 2000; 161: 1757-1759. [Abstract] [Full text]  


Sleep-Disordered Breathing:

HOLGER KRAICZI, JAN HEDNER, YÜKSEL PEKER, and LUDGER GROTE
Comparison of Atenolol, Amlodipine, Enalapril, Hydrochlorothiazide, and Losartan for Antihypertensive Treatment in Patients with Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med. 2000; 161: 1423-1428. [Abstract] [Full text]  

CHRIS O'CONNOR, KRISTINE S. THORNLEY, and PATRICK J. HANLY
Gender Differences in the Polysomnographic Features of Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med. 2000; 161: 1465-1472. [Abstract] [Full text]  

ATUL MALHOTRA, ROBERT B. FOGEL, JILL K. EDWARDS, STEVEN A. SHEA, and DAVID P. WHITE
Local Mechanisms Drive Genioglossus Activation in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med. 2000; 161: 1746-1749. [Abstract] [Full text]  


ATS/ERS WORKSHOP SUMMARY:

The Raised Volume Rapid Thoracoabdominal Compression Technique . This Workshop Summary was approved by the ATS Board of Directors, December 1999 and The ERS Executive Committee, April 2000
Am. J. Respir. Crit. Care Med. 2000; 161: 1760-1762. [Full text]  


CORRESPONDENCE:

A. Ross Hill and William Marinelli
HEART CATHETERIZATION IN ACUTE LUNG INJURY:AN OBSERVATIONAL STUDY
Am. J. Respir. Crit. Care Med. 2000; 161: 1763. [Full text]  

Lorcan McGarvey, Liam Heaney, Joseph MacMahon, Madeleine Ennis, Masaki Fujimura, C. E. Brightling, and J. D. Pavord
EOSINOPHILIC BRONCHITIS IS AN IMPORTANT CAUSE OF CHRONIC COUGH
Am. J. Respir. Crit. Care Med. 2000; 161: 1764-1765. [Full text]  


To see an article, click its [Full Text] link. To review more than one abstract at a time, check the boxes to the left of the titles you want, and click the "Get All Checked Abstract(s)" button. To see one abstract at a time, click its [Abstract] link.


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